Determining the Benefits of Gender-Affirming Surgery-A Call for Action

Nnenaya Agochukwu-Mmonu, Asa Radix, A Mark Fendrick

JAMA Surgery
JAMA Surgery

The development of validated patient-centered outcome measures with direct input from the TGNB community is a necessary and critical component of the CED model. Without standardization, findings are frequently not generalizable, and the policy discourse is guided less by rigorous, often inconsistent measures. For example, the studies examining the mental health benefit for patients undergoing gender-affirming surgeries include measures that lack standardization, evaluate different interventions (ie, surgeries are rarely done with concurrent hormone administration), include dissimilar patient populations, and use different study designs. Given this heterogenity, wide variation in reported outcomes is not unexpected; although many studies demonstrate benefit, others report that patients have unrealistic expectations or experience decision regret, including rare reports of reversal surgery.

Agochukwu-Mmonu N, Radix A, Fendrick AM. Determining the Benefits of Gender-Affirming Surgery-A Call for Action. JAMA Surgery. 2022 Mar 1;157(3):183-184